Fig. 1: The molecular mechanisms of m6A modification.
From: Nurturing gut health: role of m6A RNA methylation in upholding the intestinal barrier
m6A modification is a dynamic and reversible chemical modification. The methyltransferase complex, primarily composed of METTL3, METTL14, and WTAP, acts as the “Writers” responsible for catalyzing the formation of m6A. Demethylases, including FTO and ALKBH5, function as “Erasers” by catalyzing m6A demethylation. RNA-binding proteins, such as YTHDF1-3, YTHDC1-2, and IGF2BPs, serve as “Readers” that recognize and bind to m6A-modified mRNA transcripts. They play crucial roles in regulating RNA processing, stability, translation, and splicing in an m6A-dependent manner (Created with BioRender.com).
