Fig. 3: CD8+ T-cell exhaustion after ALI. | Cell Death Discovery

Fig. 3: CD8+ T-cell exhaustion after ALI.

From: Heat shock protein 90α reduces CD8+ T cell exhaustion in acute lung injury induced by lipopolysaccharide

Fig. 3

a Schematic illustration of the experiments carried out on CD8+ T cells isolated from the ALI/17-AAG intervention groups. b and c Typical flow patterns of PD-1 and Tim-3 in CD8+ T cells from mice at 48 h, 1 week, and 2 weeks following intratracheal injection of LPS, as well as in the 17-AAG-treated and control groups. d The statistical analysis of the expression of the two negative costimulatory molecules. e The proliferation of CD8+ T cells in each group of mice. f Representative flow cytograms showing the expression of TNF-α and IFN-γ in CD8+ T cells in each group. g Statistical analysis of TNF-α and IFN-γ in CD8+ T cells in each group. *P < 0.05, **P < 0.01.

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