Fig. 6: Effect of STAT1 interference on CD8+ T-cell exhaustion. | Cell Death Discovery

Fig. 6: Effect of STAT1 interference on CD8+ T-cell exhaustion.

From: Heat shock protein 90α reduces CD8+ T cell exhaustion in acute lung injury induced by lipopolysaccharide

Fig. 6

a Schematic illustration of STAT1 interference in CD8+ T cells. b and d Representative flow plots showing PD-1 and Tim-3 expressed by CD8+ T cells after STAT1 interference. c Statistical analysis of PD-1 and Tim-3 expressed in CD8+ T cells. e Representative flow charts of TNF-α and IFN-γ synthesis by CD8+ T cells after STAT1 interference. f Statistical analysis of TNF-α and IFN-γ expressed by CD8+ T cells. g Representative bands showing HSP90α, STAT1, and p-STAT1 expression in control and STAT1 siRNA-transfected CD8+ T cells. h Statistical analysis of HSP90α, STAT1, and p-STAT1. i The interaction of CD8+ T cell HSP90α with STAT1 and TOX. j The interaction of STAT1 with TOX. k Comparison of the proliferation rate of CD8+ T cells after STAT1 interference.

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