Fig. 1: Cigarette smoke enhanced the haematogenous and lymphatic metastatic capabilities of LSCC cells. | Cell Death Discovery

Fig. 1: Cigarette smoke enhanced the haematogenous and lymphatic metastatic capabilities of LSCC cells.

From: Nicotine-induced activation of cholinergic receptor nicotinic alpha 5 subunit mediates the malignant behaviours of laryngeal squamous epithelial cells by interacting with RABL6

Fig. 1

A Patients with HNSCC with a smoking history had a higher incidence of lymph node metastasis. B The prognosis of current smokers was poorer than that of lifelong non-smokers and reformed smokers. C The number of pack-years was higher among patients with laryngeal cancer than among those with other types of HNSCC. D Schematic representation of the establishment of mouse models of tail vein metastasis and inguinal lymph node metastasis. E Bioluminescence images of the lungs of nude mice injected with luciferase-labelled AMC-HN8 cells into the tail vein. The fluorescence intensity (F) and fluorescence area G of lung tissue sections were higher in the smoking group than in the control group. H Representative images of HE staining of lung tissue sections in the control and smoking groups. Scale bar: 20 μm. I The number of pulmonary metastatic nodules was higher in the smoking group than in the control group. J Bioluminescence images of the right lower limbs of nude mice injected with luciferase-labelled AMC-HN8 cells into the footpad. The fluorescence intensity (K) and fluorescence area (L) of the right lower limb were higher in the smoking group than in the control group. M Representative images of the inguinal lymph node metastasis model. N Representative images of enucleated inguinal lymph nodes. O Representative images of HE staining of inguinal lymph nodes. Scale bar: 20 μm. P Metastatic ratio of inguinal lymph nodes.

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