Fig. 5: CHRNA5 overexpression was associated with the metastasis and poor prognosis of LSCC. | Cell Death Discovery

Fig. 5: CHRNA5 overexpression was associated with the metastasis and poor prognosis of LSCC.

From: Nicotine-induced activation of cholinergic receptor nicotinic alpha 5 subunit mediates the malignant behaviours of laryngeal squamous epithelial cells by interacting with RABL6

Fig. 5

A Differential expression analysis of CHRNA5 in TCGA cohort. Differential expression analysis of CHRNA5 in patients with LSCC stratified based on the smoking status (B), tumour grade (C), TNM stage (D), T stage (E) and N stage (F) in TCGA cohort. Univariate (G) and multivariate (H) Cox regression analyses were performed to examine the OS of patients in TCGA cohort. I Kaplan–Meier curves were plotted to compare the OS of patients with low and high CHRNA5 expression in TCGA cohort. The median expression was used as the cut-off value. J Representative images of immunofluorescence staining demonstrating that CHRNA5 (green) was higher in LSCC tissues (smoking group) than in adjacent normal tissues in cohort 2. Scale bar: 20 μm. K Kaplan–Meier curves were plotted to compare the OS of patients with low and high CHRNA5 expression in cohort 2. The median expression was used as the cut-off value.

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