Fig. 1: Human AITL tumors show a strong upregulation of oxidative phosphorylation signature genes (oxphos). | Cell Death Discovery

Fig. 1: Human AITL tumors show a strong upregulation of oxidative phosphorylation signature genes (oxphos).

From: Dependence on mitochondrial respiration of malignant T cells reveals a new therapeutic target for angioimmunoblastic T-cell lymphoma

Fig. 1

A Heatmap for GSEA data of 52 genes (implicated in mitochondrial respiration (OXPHOS signature) for AITL patient (n = 60) and healthy LNs (n = 8). The corresponding GSEA for the OXPHOS signature genes indicated in A is shown at the right. For all genes with enrichment score >0 (black bars in the pink zone), expression is upregulated. Kolmogrov–Smimov (KS) test. B Heatmap for GSEA data for 9 genes implicated in glycolysis comparing AITL patient (n = 60) and healthy LNs (n = 8). The corresponding GSEA for the glycolytic signature genes indicated in B is shown under the heatmap. C Metabolic pathway analysis from RNAseq data from AITL patient lymphoma biopsies versus healthy lymph nodes was performed using the KEGG database. *p < 0.05; ***p < 0.001. D Correlation of PD-1 expression with a glycolytic gene expression signature or with an OXPHOS signature in hAITL tumors.

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