Fig. 1: scRNA-seq and bulk RNA-seq analysis of cell type fractions between ICC samples with and without LNM. | Cell Death Discovery

Fig. 1: scRNA-seq and bulk RNA-seq analysis of cell type fractions between ICC samples with and without LNM.

From: Mobilization and activation of tumor-infiltrating dendritic cells inhibits lymph node metastasis in intrahepatic cholangiocarcinoma

Fig. 1

Kaplan–Meier survival analyses for OS (A) and RFS (B) of 25 ICC patients with or without LNM in scPLC cohort. C Kaplan–Meier survival curves for OS of 244 ICC patients grouped by LNM status in FU-iCCA cohort. P-values were determined by log-rank test. Boxplots showing the fractions of 14 major cell types (D) and 89 cell clusters (E) identified in scRNA-seq analysis of 25 ICC samples with or without LNM. Significance was determined by unpaired Wilcoxon rank-sum test. F, G UMAP plots visualizing cells from scRNA-seq profiling of 14 ICC samples in SC-iCCA cohort. Samples grouped by LNM status and defined major cell types are distinguished by colors. H Boxplot comparing the fractions of dendritic cells between ICC samples with or without LNM in SC-iCCA cohort. I The phenotypic scores (MHC class II protein complex, Antigen processing and presentation, Myeloid dendritic cell activation, Myeloid dendritic cell chemotaxis) of dendritic cells between ICC samples with or without LNM in SC-iCCA cohort. Significance was determined by unpaired two-tailed Wilcoxon rank-sum tests. J Boxplot comparing the proportions of 22 tumor-infiltrating immune cells estimated by CIBERSORT algorithm using bulk RNA-seq data between ICC samples with or without LNM in FU-iCCA cohort. ICC intrahepatic cholangiocarcinoma, LNM lymph node metastasis, OS overall survival, RFS recurrence-free survival; *p < 0.05, **P < 0.01.

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