Fig. 2: Experimental validation of reduced DCs in ICC samples with LNM and prognostic significance. | Cell Death Discovery

Fig. 2: Experimental validation of reduced DCs in ICC samples with LNM and prognostic significance.

From: Mobilization and activation of tumor-infiltrating dendritic cells inhibits lymph node metastasis in intrahepatic cholangiocarcinoma

Fig. 2

Kaplan–Meier survival curves for OS (A) and RFS (B) of 219 ICC patients grouped by LNM status in TMA cohort. C Representative immunofluorescence images of CD45+ CD11c+ DCs (400X, scale bar, 50 μm) and corresponding statistics in surgically resected ICC samples from TMA cohort. White arrows indicate tumor-infiltrating DCs. D Representative immunohistochemistry images of positive and negative CD8 staining (400X, scale bar, 50 μm), as well as cell counts of CD8+ TILs per field in ICC. E Spearman correlation analysis for CD45+ CD11c+ DCs and CD8+ TIL counts in TMA cohort. Kaplan–Meier survival curves for OS (F) and RFS (G) of 25 ICC patients divided by proportions of intra-tumoral dendritic cells in scPLC cohort. H Overall survival analysis of 244 ICC patients grouped by fractions of tumor-resting dendritic cells in FU-iCCA cohort. Kaplan–Meier survival curves for OS (I) and RFS (J) of 219 ICC patients grouped by cell counts of CD45+ CD11c+ DCs or CD8+ T cells (K) in TMA cohort. DCs dendritic cells, TIL tumor-infiltrating lymphocytes, TMA tissue microarray. ****p < 0.0001.

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