Fig. 6: Combined Flt3L and poly I:C therapy inhibits lymph node metastasis of mIC-23 footpad tumor. | Cell Death Discovery

Fig. 6: Combined Flt3L and poly I:C therapy inhibits lymph node metastasis of mIC-23 footpad tumor.

From: Mobilization and activation of tumor-infiltrating dendritic cells inhibits lymph node metastasis in intrahepatic cholangiocarcinoma

Fig. 6

A Treatment schedule for Flt3L combined with high molecular weight poly(I:C) in mIC-23 footpad implantation model. B In vivo bioluminescence imaging was used to monitor primary footpad tumor (black arrow) and popliteal LN metastasis (red arrow). C Gross images of footpad tumors from indicated groups. Scale bar: 1 cm. D Quantification of normalized luciferase signal (left) and weight (right) of footpad tumors. E Gross images of popliteal LNs from indicated groups. H&E staining and IHC staining for CK19 of popliteal LNs (F) and incidence of LN metastasis (G) in indicated groups. H Immunofluorescence staining of DAPI, YAP, and β-catenin in metastatic popliteal LNs. White arrows indicate nuclear co-localization of YAP and β-catenin in metastatic ICC cells.

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