Fig. 1: Y RNA cleavage is activated in apoptotic cells.
From: PTBP1 protects Y RNA from cleavage leading to its apoptosis-specific degradation
A Common motif of ASRs was identified by MEME motif search. The motif, indicated in the capital letter, was plotted on Y RNA common structure. Sequences of the most abundant ASRs from each Y RNA were analyzed. B EBV lytic infection was induced by BCR stimulation using anti-human IgG antibody. After 24 h, apoptosis induction was investigated by flow cytometry. Annexin V single positivity shows early apoptotic cells and double positivity shows late apoptotic cells. C Y3 RNA and ASRs cleavage product were detected by northern blotting for latent or lytic infection of EBV (C), and with or without caspase 3 (D). Similar results were obtained in two independent experiments.
