Fig. 6: Ptbp1^mut/mut mice show higher positivity of ANA and inflammatory cytokine elevation in the serum.

A Representative of the indirect immunofluorescence assay on HEp-2 cells performed using the serum of Ptbp1^wt/wt and Ptbp1^mut/mut mice. B Results of multiplex cytokine bead assay using the serum of Ptbp1^wt/wt (n = 5) and Ptbp1^mut/mut (n = 3) mice before and after LPS administration. C Representative H&E staining of spleen and the ratio of white pulp to whole tissue area in Ptbp1^wt/wt (n = 3) and Ptbp1^mut/mut (n = 3) mice after LPS administration. Similar results were obtained in two independent experiments. Student’s t-test was used for the statistical analysis. *P < 0.05, error bars; mean ± s.d.