Fig. 4: PD-L1 was the target of YTHDF3 via m6A-modified manner. | Cell Death Discovery

Fig. 4: PD-L1 was the target of YTHDF3 via m6A-modified manner.

From: YTH domain family protein 3 accelerates non-small cell lung cancer immune evasion through targeting CD8+ T lymphocytes

Fig. 4

A In clinical samples, the correlation within YTHDF3 and PD-L1 was analyzed by in silico tool (GEPIA, http://gepia.cancer-pku.cn/index.html). B The possible m6A motif towards YTHDF3 was identified as GGACU. C In silico predictive tool (SRAMP, http://www.cuilab.cn/sramp) indicated the several m6A modified sites on PD-L1gene. D The m6A modified level was detected in NSCLC cells (A549, H1299). E FISH assay indicated the co-location of YTHDF3 and PD-L1 in the A549 cells’ cytoplasm. **p < 0.01.

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