Fig. 2: The tumor microenvironment (TME) is characterized by hypoxia, metabolic reprogramming, acidity, and immunosuppression.
From: Progression of m6A in the tumor microenvironment: hypoxia, immune and metabolic reprogramming
HIF impacts tumor cells through m6A methylation modification under hypoxia (c). There is a potential correlation between hypoxia and metabolic reprogramming, and the hypoxic environment promotes the effects of metabolic reprogramming on tumors. In addition, glucose metabolism, amino acid metabolism, and lipid metabolism affect the TME in response to m6A methylation which in turn affects tumor development (b). The m6A-mediated metabolic dysregulation generates an acidic environment, and both hypoxia and acidic environments promote the formation of immunosuppressive TME (d), and the function of multiple immune cells is also affected to promote the immunosuppressive microenvironment (a), further supporting tumor growth.
