Fig. 3: Anlotinib and eribulin had synergistic effects in RLPS. | Cell Death Discovery

Fig. 3: Anlotinib and eribulin had synergistic effects in RLPS.

From: Combination of eribulin and anlotinib exerts synergistic cytotoxicity in retroperitoneal liposarcoma by inducing endoplasmic reticulum stress

Fig. 3

A Heatmap showed synergistic scores at different concentrations. Higher score (redder color) indicates synergy in proliferation inhibition, and a lower score (bluer color) suggests an antagonistic effect. B Proliferation curves of RLPS cell strains assessed by CCK-8. In single-drug groups, proliferation was significantly inhibited compared with the control group (not marked on the graph); and proliferation in combination groups was significantly inhibited compared to single-drug groups. Data from a representative experiment (n = 3, # compared to eribulin or anlotinib). C Colony formation assay showed combination treatment reduced colony formation and colony size (n = 2, * Compared to control; # compared to eribulin with corresponding concentration). D Representative RLPS contrast microscopy image of organoids showing spheroids were sensitive to combination therapy, especially at extremely low concentrations. */# p < 0.05; **/## p < 0.01; ***/### p < 0.001.

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