Fig. 4: Combination of anlotinib and eribulin induces migration inhibition, apoptosis, and cell-cycle arrest. | Cell Death Discovery

Fig. 4: Combination of anlotinib and eribulin induces migration inhibition, apoptosis, and cell-cycle arrest.

From: Combination of eribulin and anlotinib exerts synergistic cytotoxicity in retroperitoneal liposarcoma by inducing endoplasmic reticulum stress

Fig. 4

A Transwell assays revealed that anlotinib and eribulin combination hindered migration of RLPS cells (n = 3). Cells were counted per high-power field (HP). B, C Double stained flow-cytometry showed early and late apoptosis in 94T778 and Sw872. Statistical analysis includes all cells committing apoptosis (n = 3), and error bars representing SD for respective early and late apoptosis rates. D, E Combination therapy triggered 94T778 and Sw872 cell line G2/M phase arrest. Statistical analysis including G2/M phase percentage only (n = 3). * Compared to control; # compared to eribulin (with corresponding concentration). */# p < 0.05; **/## p < 0.01; ***/### p < 0.001.

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