Fig. 5: Synergistic effect of the combination is induced by endoplasmic reticulum stress. | Cell Death Discovery

Fig. 5: Synergistic effect of the combination is induced by endoplasmic reticulum stress.

From: Combination of eribulin and anlotinib exerts synergistic cytotoxicity in retroperitoneal liposarcoma by inducing endoplasmic reticulum stress

Fig. 5

A–C Dot plots showing the top 3 KEGG pathway enrichment results of anlotinib, eribulin, and combination group. D GSEA plot featuring protein processing in endoplasmic reticulum pathway. E ERS induced by combination therapy was validated through western blot, wherein key ERS markers were upregulated and apoptosis pathway was initiated. F Rescue experiments further validated that a synergistic effect was largely induced by ERS. After applying salubrinal, synergy scores were significantly reduced.

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