Fig. 1: Thermostability, contact energy and Docking Models of p53 proteins interacting with MDM2.
From: Thermal stress, p53 structures and learning from elephants
A RMSD calculation comparing human p53 with canonical elephant p53 shows that the elephant p53 protein adopts a more thermostable conformation. B Models comparing the p53 structure before and after MD simulation. The BOX-I motif is more exposed in the elephant compared to human. C Contact energy calculation of elephant p53 LoxoPPs including each Type of BOX-I (A–F). D Docking capacity of full-length putative proteins encoding each Type of p53 BOX-I with MDM2 at different temperatures (normal environmental temperature, 300 K (corresponding to 26.85 °C); normal body temperature, 309.15 K (corresponding to 36 °C); and hyperthermia, 315.15 K (corresponding to 42 °C)). E Docking models of each interaction calculated in “(D)”.
