Fig. 5: (R)-CRZ and (S)-CRZ ameliorate renal ischemia-reperfusion injury (IRI) caused by ferroptosis in a mouse model.
From: Crizotinib and its enantiomer suppress ferroptosis by decreasing PE-O-PUFA content
A, B (R)-CRZ A and (S)-CRZ B ameliorate renal ischemia reperfusion injury (IRI) indicated by reduced serum urea nitrogen and creatinine levels. C, D Fer-1 and (R)-CRZ ameliorate kidney damage caused by IRI. E (R)-CRZ decreases the 4-HNE signal in the mouse kidney with ischemia-reperfusion injury. F, G (S)-CRZ ameliorate kidney damage caused by IRI. H (S)-CRZ decreases the 4-HNE signal in the mouse kidney with ischemia-reperfusion injury. Representative Hematoxylin and eosin (H & E) staining pictures showed pathological morphology of kidney tissue (C, F). Quantification of renal damage from mice of indicated groups (D, G). Representative immunohistochemistry (IHC) staining pictures of 4-HNE in kidney sections from control and compounds pretreated mice were shown (E, H).
