Fig. 3: MDH2 enhances the sensitivity of ccRCC to ferroptosis. | Cell Death Discovery

Fig. 3: MDH2 enhances the sensitivity of ccRCC to ferroptosis.

From: MDH2 regulates the sensitivity of clear cell renal cell carcinoma to ferroptosis through its interaction with FSP1

Fig. 3

A, B Response curves of ccRCC cells to RSL3 (A) and erastin (B). The statistical analysis comes from biological replicates and the experiment was repeated three times. Data was presented as mean ± SD. C Morphology of ccRCC cells treated with RSL3 (0.2 μM, 6 h). D Flow cytometry analysis of cell death in ccRCC cells treated with RSL3 (0.5 μM, 6 h). The statistical analysis comes from technical replicates and the experiment was repeated three times. Data was presented as mean ± SD. E Flow cytometry analysis of lipid peroxidation in ccRCC cells treated with RSL3 (0.1 μM, 6 h). The statistical analysis comes from technical replicates and the experiment was repeated three times. Data was presented as mean ± SD. (*P < 0.05, **P < 0.01, ***P < 0.001, and ns not significant.).

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