Fig. 3: KIFC1 promoted centrosome amplification dependent on PLK4. | Cell Death Discovery

Fig. 3: KIFC1 promoted centrosome amplification dependent on PLK4.

From: KIFC1 depends on TRIM37-mediated ubiquitination of PLK4 to promote centrosome amplification in endometrial cancer

Fig. 3

A The mRNA expression of PLK4 in EC cell lines. B The protein expression of PLK4 in EC cell lines. C The mRNA expression of PLK4 in KIFC1-overexpressed HEC-1A and KIFC1-knockdown Ishikawa cells. D The protein expression of PLK4 in KIFC1-overexpressed HEC-1A and KIFC1-knockdown Ishikawa cells. E The mRNA expressions of PLK4 and KIFC1 in PLK4-overexpressed and KIFC1-knockdown EC cell lines (HEC-1A and Ishikawa). F The protein expressions of PLK4 and KIFC1 in PLK4-overexpressed and KIFC1-knockdown EC cell lines (HEC-1A and Ishikawa). G The immunofluorescence analysis with γ-tubulin and α-tubulin antibodies in PLK4-overexpressed and KIFC1-knockdown EC cell lines (HEC-1A and Ishikawa) (scale bar: 10 μm). *P < 0.05, **P < 0.01, #P < 0.05, ##P < 0.01.

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