Fig. 1: RNA-seq data revealed the up-regulation of Notch and down-regulation of Wnt pathway upon the loss of p21 function in the background of Werner syndrome. | Cell Death Discovery

Fig. 1: RNA-seq data revealed the up-regulation of Notch and down-regulation of Wnt pathway upon the loss of p21 function in the background of Werner syndrome.

From: p21 Regulates Wnt-Notch balance via DREAM/MMB/Rb-E2F1 and maintains intestinal stem cell homeostasis

Fig. 1

A The RNA-seq data showing the up-regulated Notch pathway and down-regulated Wnt pathway in p21G2TKO mouse tissue. B The top 50 down-regulated Wnt pathway genes in p21G2TKO mouse tissue revealed by GSEA analysis. C The top 50 up-regulated Notch pathway genes in p21G2TKO mouse tissue revealed by GSEA analysis.

Back to article page