Fig. 5: Overexpression of p21 rescued the imbalance of Wnt-Notch, and shifted the DREAM/MMB/Rb-E2F1 complex towards its inhibitory function. | Cell Death Discovery

Fig. 5: Overexpression of p21 rescued the imbalance of Wnt-Notch, and shifted the DREAM/MMB/Rb-E2F1 complex towards its inhibitory function.

From: p21 Regulates Wnt-Notch balance via DREAM/MMB/Rb-E2F1 and maintains intestinal stem cell homeostasis

Fig. 5

A Overexpression of p21 in p21G2TKO cells restored the expression of Wnt3, β-Catenin proteins, and suppressed the expression of Nocth1, Hes1, and Rbpj. B Overexpression of p21 suppressed the expression of MMB/E2F1 proteins and restored the inhibition DREAM/Rb proteins. C The MMB down-stream proteins and cell cycle related proteins were also suppressed by p21 overexpression. D Immunofluorescence staining indicated the up-regulation of Wnt3 and β-Catenin, and suppression of Nocth1, Hes1 protein level after overexpression of p21.

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