Fig. 2: The function of ferroptosis in H. pylori infection gastric cancer. | Cell Death Discovery

Fig. 2: The function of ferroptosis in H. pylori infection gastric cancer.

From: Infection of Helicobacter pylori contributes to the progression of gastric cancer through ferroptosis

Fig. 2

H. pylori infection could be up-regulated or downregulated in gastric mucosal cells. H. pylori mediated the expression of TCF4 and then regulated GPX4 and ROS, influenced cell ferroptosis. Also, H. pylori and its infection-regulated PHKG2 expression mediated ALOXs influenced ferroptois. Furthermore, the OMVs and CagA all play an important role in the regulation of ferroptosis mediated by H. pylori.

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