Fig. 7: Schematic diagram showing the role of RRM1 in regulating DSB repair. | Cell Death Discovery

Fig. 7: Schematic diagram showing the role of RRM1 in regulating DSB repair.

From: RRM1 promotes homologous recombination and radio/chemo-sensitivity via enhancing USP11 and E2F1-mediated RAD51AP1 transcription

Fig. 7

RRM1 interacts with USP11 in the cytoplasm. IR induces the entry of RRM1 into the nucleus while promoting the entry of USP11. USP11 in the nucleus can exert a deubiquitination function on E2F1 and inhibit the ubiquitination degradation of E2F1. High levels of E2F1 promote the transcription of RAD51AP1, thereby enhancing HR and the radiation sensitivity of tumor cells.

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