Fig. 2: Animal models of brain metastases radiation response. | Cell Death Discovery

Fig. 2: Animal models of brain metastases radiation response.

From: Genomic predictors of radiation response: recent progress towards personalized radiotherapy for brain metastases

Fig. 2

Preclinical models of brain metastases may use cancer cell lines, patient-derived tissue, or co-culture models as the source of tumor cells. These may then be administered through heterotopic or orthotopic transplantation. After engraftment, radiation treatment can be given to model whole-brain radiation therapy (WBRT) or stereotactic radiosurgery (SRS). Subsequent readouts may include transcriptomic, histological, and radiologic data to identify clinically relevant biomarkers of radiation response.

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