Fig. 1: IDO1 expression was upregulated in patients with GBM. | Cell Death Discovery

Fig. 1: IDO1 expression was upregulated in patients with GBM.

From: IDO1 inhibits ferroptosis by regulating FTO-mediated m6A methylation and SLC7A11 mRNA stability during glioblastoma progression

Fig. 1

A The mRNA levels of IDO1 were compared between normal brain tissues (n = 2642), low-grade gliomas (LGG) (n = 513) and high-grade gliomas (GBM) (n = 153) tissues in the TCGA database. B The mRNA levels of IDO1 were compared between LGG (n = 443) and GBM (n = 249) tissues in CGGA database. C Immunohistochemistry (IHC) staining was used to detect the expression of IDO1 in GBM tissues and adjacent normal tissues from the clinical GBM specimens (n = 12), scale bar = 100 μm or 20 μm. Correlation of IDO1 mRNA levels in gliomas and isocitrate dehydrogenase (IDH) genetype (D) or 1p/19q codeletion status (E) was analyzed in CGGA database. Kaplan–Meier curves of overall survival (OS) of glioma patients from TCGA database (F) and CGGA database (G) were determined by log-rank test. The data are represented as the mean ± standard deviation (SD); *p < 0.05, **p < 0.01, ***p < 0.001, ns not significant.

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