Fig. 2: Colorectal cancer cells rely more on oxidative phosphorylation under acidic microenvironment. | Cell Death Discovery

Fig. 2: Colorectal cancer cells rely more on oxidative phosphorylation under acidic microenvironment.

From: Autophagic flux-lipid droplet biogenesis cascade sustains mitochondrial fitness in colorectal cancer cells adapted to acidosis

Fig. 2

A Viability of CRC and CRC-AA cells treated with 2-DG (5 mM) measured by MTT assay. B Viability of CRC and CRC-AA cells treated with oligomycin (Olig, 1 μM) checked by MTT assay. C Apoptotic levels of CRC and CRC-AA cells treated with 2-DG (5 mM) or oligomycin (1 μM) checked by flow cytometry. D Proliferation of CRC and CRC-AA cells treated with 2-DG (5 mM), etomoxir (etom, 50 μM) for 48 h were determined by EdU assay. E The content of acetyl-CoA was detected in CRC and CRC-AA cells treated with 2-DG (5 mM) or etomoxir (50 μM) for 48 h. *p < 0.05, **p < 0.01, ***p < 0.001, ns indicates p > 0.05.

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