Fig. 4: METTL1 deficiency reduces xenograft tumor growth in vivo. | Cell Death Discovery

Fig. 4: METTL1 deficiency reduces xenograft tumor growth in vivo.

From: METTL1 coordinates cutaneous squamous cell carcinoma progression via the m7G modification of the ATF4 mRNA

Fig. 4

Knockdown of METTL1 inhibited HSC-1 xenograft tumor growth (A) and reduced tumor weight (B). Knockdown of METTL1 inhibited A431 xenograft tumor growth (C) and reduced tumor weight (D). E, F The protein levels of PCNA in tumor tissues were detected by IHC and western blot. The IOD of PCNA was calculated. β-Tubulin was used for the normalization control. The relative protein level was calculated. G The mRNA level of Pcna was evaluated by qRT-PCR. Data are shown as mean ± SEM. n = 5. **P < 0.01, ***P < 0.001.

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