Fig. 1: Multiple post-transcriptional modifications regulate cancer progression via manipulating the activity of the Hippo signalling pathway. | Cell Death Discovery

Fig. 1: Multiple post-transcriptional modifications regulate cancer progression via manipulating the activity of the Hippo signalling pathway.

From: YAP/TAZ-Hippo pathway mediates the tumorigenesis of various cancers through post-translational modification represented by ubiquitination

Fig. 1

MST1/2, LATS1/2 and YAP/TAZ are the core regulatory components of the Hippo signalling pathway. Upon activation of the Hippo pathway, LAST1/2 promotes YAP/TAZ phosphorylation, inactivating them. YAP/TAZ act as transcriptional activators and, together with TEADs (a pivotal family of transcription factors), promote the transcriptional process of multiple downstream target genes, thereby affecting various tumour biological processes. The blue arrow indicates that the transcription of the target gene is upregulated through specific post-transcriptional modifications (PTMs), whereas the red arrow represents transcriptional repression.

Back to article page