Fig. 2: Localization of the hERG1/β1 integrin complex in lipid rafts in human primary PDAC samples. | Cell Death Discovery

Fig. 2: Localization of the hERG1/β1 integrin complex in lipid rafts in human primary PDAC samples.

From: Targeting the hERG1/β1 integrin complex in lipid rafts potentiates statins anti-cancer activity in pancreatic cancer

Fig. 2

A Representative IHC images of scDb-hERG1-β1 and caveolin-1 staining in normal sample (top panel) and PDAC samples (bottom panels). The normal sample is positive for caveolin-1 and negative for scDb-hERG1-β1. The PDAC sample in the middle panel is positive for scDb-hERG1-β1 and caveolin-1. The PDAC sample in the bottom panel is negative for scDb-hERG1-β1 and caveolin-1. Scale bar: 100 μm. B Expression of hERG1-β1 complex, caveolin-1 in normal pancreas and PDAC samples. The number of negative and positive (and the corresponding percentage) samples for the two biomarkers are reported. The p values of Fisher’s Exact test and Pearson Correlation Coefficient are reported. C Heat map and Pearson correlation coefficient between scDb-hERG1-β1 and caveolin-1 in normal samples (left panel) and in PDAC samples (right panel). D Representative IF images showing co-localization of hERG1-β1 integrin complex and caveolin-1 in a PDAC tissue sample. Sample was stained with scDb-hERG1-β1 alexa-488 conjugated and anti-caveolin-1 antibody revealed with Alexa-546-anti-mouse secondary antibody. From left to right, scDb-hERG1-β1-alexa488, caveolin-1, Hoechst staining and Merge images are reported (scale bar: 100 µm).

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