Fig. 8: Effects of SIM and scDb-hERG1-β1 treatment in vivo in a PDAC mouse model. | Cell Death Discovery

Fig. 8: Effects of SIM and scDb-hERG1-β1 treatment in vivo in a PDAC mouse model.

From: Targeting the hERG1/β1 integrin complex in lipid rafts potentiates statins anti-cancer activity in pancreatic cancer

Fig. 8

A Time course of the volumes of tumor masses of PANC-1 cells (top panel) growing in mice treated with SIM 40 mg/kg, SIM 80 mg/kg and combination with scDb-hERG1-β1 16 mg/kg. P Values obtained with one-way ANOVA analysis at day 51 of experiment are reported below: CTR vs. SIM 40 p: 0.6859; CTR vs. SIM 40+ scDb-hERG1-β1 p: 0.5012; CTR vs. SIM 80 p: 0.0415; CTR vs. SIM 80+ scDb-hERG1-β1 p: 0.0144; SIM 40 vs. SIM 40+ scDb-hERG1-β1 p: 0.9996; SIM 40 vs. SIM 80 p: 0.6028; SIM 40 vs. SIM 80+ scDb-hERG1-β1 p: 0.2637; SIM 40+ scDb-hERG1-β1 vs. SIM 80 p: 0.7959; SIM 40+ scDb-hERG1-β1 vs. SIM 80+ scDb-hERG1-β1 p: 0.4126; SIM 80 vs. SIM 80+ scDb-hERG1-β1 p: 0.1423. Schedule of treatment (bottom panel). B Representative US images of tumor masses with rendering from PANC-1 cells at day 51 of mice untreated (CTR) and treated with SIM 40 mg/kg, SIM 80 mg/kg and combination with scDb-hERG1-β1 16 mg/kg. C Photoacoustic images (left panels) and related bar graph of HB total levels (right panel). D Representative IHC images of ki67 staining of tumor masses (left panels) and corresponding bar graph (right panel) of mice untreated (CTR) and treated with SIM 40 mg/kg, SIM 80 mg/kg and combination with scDb-hERG1-β1 16 mg/kg; 100 µm scale bar. The p values of Log Rank Test for Survival analysis was the following: CTR vs SIM 80: 0.7428; CTR vs SIM 40: 0.9271; CTR vs SIM 40 ± scDb-hERG1-β1: 0.1612. **P < 0.01 and ***P < 0.001. CTR control, SIM simvastatin, HbTOT total hemoglobin.

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