Fig. 3: Mice deficient in p63 are prone to chronic inflammation in multiple organs.
From: TAp63γ is the primary isoform of TP63 for tumor suppression but not development
A The percentage of WT, TAp63+/−, p63γ+/−, and p63γ−/− mice with chronic inflammation in 3 or more organs. B Representative images of H&E-stained liver, lung, pancreas, and kidney tissues from WT, TAp63+/−, p63γ+/−, and p63γ−/− mice. C Fold induction of four inflammatory pathways in p63γ-KO C2C12 cells as compared to isogenic control cells analyzed by KEGG analyses. D–F Levels of p63γ, IL17α, TNFα, IL-1β, IL-18, and actin transcripts in isogenic control vs. p63γ-KO C2C12 cells (D), WT vs. p63γ-KO liver (E), or WT vs. p63γ-KO spleen (F).
