Fig. 5: Loss of p63g leads to the accumulation of triglycerides and cholesterol esters via SCD1.
From: TAp63γ is the primary isoform of TP63 for tumor suppression but not development
A UMAP plot of thirteen cell clusters from WT mouse kidneys. B Schematic diagram of the functions of SCD1 to converts palmitate (16:0) and stearate (18:0) to palmitoleate (16:1) and oleate (18:1), respectively. C SCD1 is induced by loss of p63γ in three cell clusters of mouse kidney cells. D SCD1 is induced by loss of either p63α or p63γ in Mia-PaCa2 cells. E The level of the SCD1 promoter associated with p63α or p63γ protein was measured by ChIP assay. F, G The levels of triglyceride (TAG) (F) and cholesterol esters (CEs) (G) were measured in isogenic control (con), p63α−/− and p63γ−/− Mia-PaCa2 cells transfected with scramble siRNA (Scr) or si-SCD1.
