Fig. 8: NINJ1-mediated plasma membrane rupture of pyroptotic endothelial cells exacerbates blood-brain barrier destruction caused by neutrophil extracellular traps in traumatic brain injury. | Cell Death Discovery

Fig. 8: NINJ1-mediated plasma membrane rupture of pyroptotic endothelial cells exacerbates blood-brain barrier destruction caused by neutrophil extracellular traps in traumatic brain injury.

From: NINJ1-mediated plasma membrane rupture of pyroptotic endothelial cells exacerbates blood-brain barrier destruction caused by neutrophil extracellular traps in traumatic brain injury

Fig. 8

NETs induced by TBI interact with the TLR4 of bECs and then activate NF-κB to transfer into the nucleus, which promotes NLRP3 inflammasome formation. Then, activated caspase-1 from the NLRP3 inflammasome cleaved GSDMD and released GSDMD-N, perforating the GSDMD pores and increasing the BBB permeability. Furthermore, GSDMD pores activate NINJ1 oligomerization on the cell membrane, which mediates PMR. HMGB1 promotes neutrophil formation in NETs.

Back to article page