Fig. 3: DDR1-IN-1 induced autophagy in MPNST. | Cell Death Discovery

Fig. 3: DDR1-IN-1 induced autophagy in MPNST.

From: Discoidin domain receptor inhibitor DDR1-IN-1 induces autophagy and necroptotic cell death in malignant peripheral nerve sheath tumor

Fig. 3

The autophagy activity was visualized through the Acridine Orange (AO) assay (A). The fluorescent images represent the S462 cells under AO assay in response to 0–15 μM DDR1-IN-1 treatment for 24 hours. Green fluorescent represents the cytoplasm and nucleus; red fluorescent indicates the acidic vacuoles and the white arrows point to the cells undergoing autophagy. Transcriptomic data are also presented. B–G RNAs were collected after treating S462 cells with 10 μM DDR1-IN-1 for 24 hours. The RNA-seq was performed and the data was analyzed (n = 3). GSEA analysis data represents the correlation between DDR1-IN-1-treated MPNST cells and autophagy.

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