Fig. 6: DDR1-IN-1 induced synergistic cell death with other anti-MPNST agents. | Cell Death Discovery

Fig. 6: DDR1-IN-1 induced synergistic cell death with other anti-MPNST agents.

From: Discoidin domain receptor inhibitor DDR1-IN-1 induces autophagy and necroptotic cell death in malignant peripheral nerve sheath tumor

Fig. 6

S462 MPNST cells were treated with 5 μM DDR1-IN-1 combined with 0-100 μM doxorubicin (A), etoposide (B), PD0325901 (C), or SHP099 (D) for 48 hours. Cell viability was evaluated through the MTT assay and the IC50 was calculated. The cell viability of cells exposed to 5 μM DDR1-IN-1 and/ or 10 μM anti-MPNST agents were plotted as bar charts as indicated, and the p-value was demonstrated (n = 3). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.

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