Table 3 PDAC driver genes mutation status of the employed organoids.

From: Investigating synthetic lethality and PARP inhibitor resistance in pancreatic cancer through enantiomer differential activity

Organoid

KRAS

TP53

CDKN2A

SMAD4

PDM-37

G12D (MV)

K139Rfs*311 (FV)

R87_D92del

Q422X

PDM-41

G12V (MV)

P47R (MV)

599delA (FD)

M237I (MV)

*29G>C (SNV)

–

PDM-106

G12V (MV)

P47R (MV)

*29G>C (SNV)

–

PT-127

G13D (MV)

P72R (MV)

599delA (FD)

*29G>C (SNV)

–

PT-291

G12D (MV)

599delA (FD)

710_711insA (I)

*29G>C (SNV)

–

  1. Data obtained from [37].
  2. FD frameshift deletion, FV frameshift variant, I insertion, MV missense variant, SNV single nucleotide variant.
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