Table 2 Expression, function and molecular mechanism of CRIP family proteins in different tumor types.
CRIP members | Expression level | Function | Mechanism | Cancer | Cell line | References |
|---|---|---|---|---|---|---|
CRIP1 | ↑ | Facilitate cancer stem-like properties | CRIP1/BBOX1/β-catenin | Hepatocellular carcinoma | Hun7, Hep3B, MHCC-97H | [4] |
CRIP1 | ↑ | Lymphangiogenesis↑lymphatic permeability↑proliferative and metastatic capacities↑ | CRIP1-CREB1 ↑ → VEGFC ↑ CCL5↑ | Gastric cancer | MGC-803, HGC-27 | [10] |
CRIP1 | ↑ | Cell migration and invasion↑ | / | Colorectal cancer | SW620,HT29 | [12] |
CRIP1 | Related to HER2 | Tumor-suppressive function proliferation and invasion↓ | CRIP1 ↓ → phosphorylation of MAPK and Akt↑ | Breast cancer | T47D,BT474 | [13] |
CRIP1 | ↑ | Promote proteasome activity and autophagosome maturation, cell proliferation and invasion↑ | CRIP1/USP7/PA200 complex | Multiple myeloma | KMS11,NCI-H929,ARP1 | [35] |
CRIP1 | ↑ | Cell migration and invasion↑ EMT↑ | Activate the Wnt/β-catenin pathway | Epithelial ovarian cancer | A2780,OVCAR3 | [37] |
CRIP1 | ↑ | Cell migration and invasion↑ EMT↑ | Activate the Wnt/β-catenin pathway | Cervical cancer | Hela,Siha,ME180,Caski,MS751 | [38] |
CRIP1 | ↑ | Cell migration and invasion↑ EMT↑ | Activate the GSK 3/mTOR signaling pathway | Colorectal cancer | SW620,LoVo | [40] |
CRIP1 | ↑ | Cell proliferation↑ | Negatively regulating Fas-related pathway | Colorectal cancer | LS174T,RKO,HT29,HCT116,SW480,SW620 | [43] |
CRIP1 | ↑ | Proliferation, migration, and invasion↑an independent prognostic marker | Silencing CRIP1 induces apoptosis and G1 arrest | Thyroid carcinoma | K1, TPC-1, TT, SW579 | [44] |
CRIP1 | ↑ | Cell growth, migration and colony formation↑chemosensitivity to Ara-C↓ | Activate the Wnt/β-catenin pathway | Acute myeloid leukemia | U937, THP1 | [45] |
CRIP1 | ↑ | Proliferation↑ | May be involved in the JAK-STAT signaling pathway | Ovarian cancer | A2780, SKOV-3 | [53] |
CRIP1 | Frequently upregulated | Fostered an immunosuppressive tumor microenvironment | CRIP1/NF-κB/CXCL axis | Pancreatic ductal adenocarcinoma | MiaCaPa-2,PANC-1,SW1990,BxPc-3,CFPAC-1 | [55] |
CRIP1 | ↑ | Cell proliferation, development | Related to FGF-8 | Prostate cancer | PC-3 | [62] |
CRIP1 | ↓ | Inhibition of mitochondrial function | Suppress the protein levels of TFAM | Cutaneous melanoma | SK-MEL-2, A375 | [64] |
CRIP1 | ↓ | Suppressor of tumor growth | Gene silencing | Esophageal squamous cell carcinoma | KYSE | [65] |
CRIP1 | ↑ | Proliferation, migration, and invasion↑ | CRIP1/Ras/PI3K/AKT | Hepatocellular carcinoma | HepG2,HCC-LM3 | [67] |
CRIP1 | ↓ | Tumor proliferation and immune infiltration | / | Nasopharyngeal carcinoma | / | [78] |
CRIP1 | ↑ | Possible biomarker and therapeutic target | Hsa-miR-221-5p | Renal cell carcinoma | / | [80] |
CRIP1 | / | Predict risk of recurrence | DNA methylation | Prostate cancer | / | [82] |
CRIP1 | ↑ | Prognosis | / | Acute myeloid leukemia | / | [93] |
CRIP2 | ↑ | Mitophagy-related gene | / | Multiple myeloma | / | [46] |
CRIP2 | / | Mitochondrial apoptosis resistance | PRC2 ↓ → CRIP2 ↑ → TRAP1↑ | T-cell acute lymphoblastic leukemia | CCRF-CEM,DND41,PF382,MOLT4,RPMI8402,Jurkat | [47] |
CRIP2 | ↓ | Colony formation, growth, and invasion abilities↓ | CRIP2 ↑ → caspases 3 and 9 ↑ →apoptosis↑ | esophageal squamous cell carcinoma | 81T, EC1,EC18,HKESC-2,KYSE,SLMT,TTn-6 | [48] |
CRIP2 | ↓ | An immune-related dangerous gene | / | Colon cancer | / | [56] |
CRIP2 | ↓ | Inhibit glycolysis tumor-suppressive function | miR-365-HOXA9-HIF-1α | Cutaneous squamous cell carcinoma | A431 | [70] |
CRIP2 | ↑ | Impact the X-ray radiosensitivity of NSCLC | Regulate the occurrence of apoptosis and cell cycle arrest | Non-small cell lung cancer | A549-R11 | [84] |
CRIP3 | / | Prognostic biomarker | / | Squamous cell carcinoma of the head and neck | / | [72] |
CRIP3 | / | Prognosis | CRIP3 DNA methylation ↓ →poorer prognosis | Lung squamous cell carcinoma | / | [73] |
CRIP3 | / | Prognosis | Methylation | Prostate cancer | / | [74] |
