Fig. 8: FASN expression is negatively correlated with PLA2G4B in CRC patients.
From: FASN promotes lipid metabolism and progression in colorectal cancer via the SP1/PLA2G4B axis
Eighty CRC samples and normal adjacent tissues were subjected to IHC analysis to assess the expression of FASN (A) and PLA2G4B (B). Representative IHC images showing FASN (A) and PLA2G4B (B) staining in CRC sections. Scale bar, 100 μm. C The correlation between FASN expression and PLA2G4B expression in CRC patients was analyzed. D CRC patients with high FASN expression had a significantly poorer prognosis than patients with low FASN expression. E CRC patients with high PLA2G4B expression had a significantly better prognosis than patients with low PLA2G4B expression. F Kaplan–Meier curves for the overall survival of CRC patients according to the expression of FASN and PLA2G4B in the four patient subtypes. G Multivariate Cox regression analysis was conducted to evaluate the association between FASN expression and overall survival, as depicted in the forest plots. Statistical significance was assessed via Student’s t-test. Significance levels are shown as ***P < 0.001.
