Fig. 3: Gilteritinib induces apoptosis and cell-cycle arrest in vitro.
From: Antitumor activity of gilteritinib, an inhibitor of AXL, in human solid tumors
A–C KYSE30, A2780, and HGC-27 cells were treated with 0, 0.3, 1, and 3 μM gilteritinib for 24 h, before analyzing the proportion of apoptotic cells by flow cytometry, with the percentage of Annexin V/PI-positive cells depicted in bar charts. D–F Cells were treated with 0, 0.3, 1, and 3 μM gilteritinib for 24 h, before determining the cell cycle by flow cytometry, with the cell cycle distributions depicted in bar charts. Scale bars: 100 µm. Data are presented as the mean ± standard error of the mean (SEM); the statistical significance was determined by unpaired t-test (*p < 0.05; **p < 0.01; ***p < 0.001).
