Fig. 8: Inhibitory effects of gilteritinib on EC PDXO growth.
From: Antitumor activity of gilteritinib, an inhibitor of AXL, in human solid tumors
A IHC staining of AXL expression in EC PDXs and their corresponding PDXOs. DAPI nuclear stain is shown in blue. Images were captured at 400× magnification. Scale bars: 20 µm. B EC241 and EC291 PDXO models were treated with the indicated concentrations of gilteritinib from 0 h to 144 h. The organoid size (%) was calculated using Incucyte S3 Zoom software based on phase-contrast images. C Brightfeld images of PDXOs treated with gilteritinib from 0 h to 144 h. Scale bar: 300 μm. Each data point represents triplicate wells.
