Fig. 7: Ketogenic diet reduces CAV1 and SLC7A11 expression and tumor burden in MIA PaCa-2 model.
From: Integrative insights into the role of CAV1 in ketogenic diet and ferroptosis in pancreatic cancer
A Blood ketone (left) and glucose (right) levels of normal or ketogenic diet nude mice bearing MIA PaCa-2 xenograft tumor. B Tumor weight and volume of normal or ketogenic diet nude mice bearing MIA PaCa-2 xenograft tumor. C Representative image of multiplex immunofluorescence staining for CAV1 (green) and SLC7A11 (red) on MIA PaCa-2 model fed with a normal diet. D Representative image of multiplex immunofluorescence staining for CAV1 (green) and SLC7A11 (red) on MIA PaCa-2 model fed with a ketogenic diet. E Percentage of CAV1+ (left) or SLC7A11+ (right) cells per field on MIA PaCa-2 xenograft tumor tissue sections. F Percentage of gradient CAV1+ (left) or SLC7A11+ (right) cells on MIA PaCa-2 xenograft tumor tissue sections. G Representative image of multiplex immunofluorescence staining for 8-OHdG (green) and 4-HNE (red) on MIA PaCa-2 model fed with a normal diet. H Representative image of multiplex immunofluorescence staining for 8-OHdG (green) and 4-HNE (red) on MIA PaCa-2 model fed with a ketogenic diet. I Percentage of 4-HNE+ (left) or 8-OHdG+ (right) cells per field on MIA PaCa-2 xenograft tumor tissue sections. J Correlation scatter plot of mean fluorescence intensity (MFI) between CAV1 and SLC7A11 on MIA PaCa-2 xenograft tumor tissue sections. A, B, E, F, I Data were shown as the mean ± SD, n = 6, two-tailed t-test or two-way ANOVA. J Spearman correlation analysis. **P < 0.01, ***P < 0.001, and ****P < 0.0001.
