Fig. 8: Impact of PGK1 and PCMT1 knockdown on PI3K/AKT/mTORC signaling in BC cell lines. | Cell Death Discovery

Fig. 8: Impact of PGK1 and PCMT1 knockdown on PI3K/AKT/mTORC signaling in BC cell lines.

From: Development of a breast cancer invasion score to predict tumor aggressiveness and prognosis via PI3K/AKT/mTOR pathway analysis

Fig. 8

A mRNA expression of PGK1 and PCMT1 in MCF7 and MDA-MB-231 cells. B Knockdown efficiency of PGK1 and PCMT1 genes in MCF7 and MDA-MB-231 using shRNAs. C Proliferation curves of MDA-MB-231 cells after PGK1 and PCMT1 gene knockdown. D Proliferation curves of MCF7 cells after PGK1 and PCMT1 gene knockdown. E Colony formation in MCF7 and MDA-MB-231 cells with PGK1 and PCMT1 knockdown. Statistical significance: *P < 0.05, **P < 0.01, ***P < 0.001.

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