Fig. 1: glial markers in the nonhuman spinal cord display sex and age dimorphisms. | Cell Death Discovery

Fig. 1: glial markers in the nonhuman spinal cord display sex and age dimorphisms.

From: Sex and age differences in glia and myelin in nonhuman primate and human spinal cords: implications for pathology

Fig. 1

Quantification of the expression of IBA1 (A), GFAP (B), CNPase (C), BRCA1 (O) and S100β (R) in midlife and old males and females. Representative brightfield micrographs of IBA1 (D, G & J), GFAP (E, H & K), CNpase (F, I & L), BRCA1 (M, P & S) and S100β (N, Q & T) expression in the nonhuman primate spinal cord. Sections from the same animal, an old male, are shown for all staining (D-L, N, Q & T), except for BRCA1, where sections from an old female are presented in (M, P & S). Three different magnifications are shown for each marker. Scale bars (D-I, M-N and P-Q): 200 µm; (J-L and S-T): 100 µm. Statistics *p < 0.05, **p < 0.01 and ***p < 0.001, un-paired t-test. Lemurs: n = 3 animals per group. For each individual, we quantified 10 spinal cord sections for IBA1, 8 sections for GFAP, 9 sections for CNPase, 7 sections for BRCA1 and S 100β. Sections were 14 µm thick and spaced 630 µm apart.

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