Fig. 1: Nuclear FBP1 is degraded through the ubiquitin-proteasome pathway. | Cell Death Discovery

Fig. 1: Nuclear FBP1 is degraded through the ubiquitin-proteasome pathway.

From: MLN4924 suppresses tumor metabolism and growth of clear cell renal cell carcinoma by stabilizing nuclear FBP1

Fig. 1

A Western blot was performed to analyze FBP1 expression with the treatment of DMSO, MG132 (10 μM), or NH4Cl (10 mM) in 786-O cells. B Immunoprecipitation and Western blot with the indicated antibodies were performed to determine the level of FBP1 ubiquitylation in HEK293T cells. C Western blot was performed to assess the cytoplasmic and nuclear expression of FBP1 after the treatment of DMSO, MG132 (10 μM) or NH4Cl (10 mM) in 786-O cells.

Back to article page