Fig. 5: The combination of MLN4924 and BSO effectively suppresses tumor growth in vivo. | Cell Death Discovery

Fig. 5: The combination of MLN4924 and BSO effectively suppresses tumor growth in vivo.

From: MLN4924 suppresses tumor metabolism and growth of clear cell renal cell carcinoma by stabilizing nuclear FBP1

Fig. 5

A GSH levels were measured in different groups in 786-O cells. B ROS levels were measured in 786-O cells knocked down with FBP1 and in the control group. C ROS levels were measured in 786-O cells knocked down with CUL4B and in the control group. D Schematic of the xenograft experiments. 786-O cells were subcutaneously injected into athymic BALB/c nude mice and treated as indicated (n = 5). E Tumors were harvested at the end of experiment and photographed. F The tumor growth was measured and plotted. The tumor volume (G) and weight (H) were calculated. I Representative images of FBP1 IHC staining in tumor specimens from different mouse groups. J GSH levels were measured in tumor specimens from different mouse groups. K ROS levels were measured in tumor specimens from different mouse groups. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.001.

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