Fig. 1: Sotorasib causes cardiac injury in mice.
From: Sotorasib-impaired degradation of NEU1 contributes to cardiac injury by inhibiting AKT signaling
Male C57BL/6J mice were treated with 0.5% CMC-Na or sotorasib (300 mg/kg/d or 600 mg/kg/d) by gavage for 28 days. A Cardiac function was examined by echocardiography, showing the percentage of EF and FS (n = 6). B Ratio of heart weight to tibia length (n = 6). C Serum levels of CK-MB, CK and LDH were analyzed (n = 6). D mRNA levels of cardiac remodeling indicators Myh6, Myh7, Nppa and Nppb (n = 6). E–G Cardiac sections stained with H&E, Sirius Red and Masson (n = 3). Scale bars: 50 μm. H Cardiac sections stained with WGA (n = 3). Scale bars: 25 μm. Data expressed as mean ± SD, ***, p < 0.0001, **, p < 0.01, *, p < 0.05, ns, no significance (vs. Vehicle).
