Fig. 2: Intravitreal injection of MSC-sEVs alleviated oxidative stress damage and apoptosis in the retina of diabetic rats. | Cell Death Discovery

Fig. 2: Intravitreal injection of MSC-sEVs alleviated oxidative stress damage and apoptosis in the retina of diabetic rats.

From: MiR-125a-5p in MSC-derived small extracellular vesicles alleviates Müller cells injury in diabetic retinopathy by modulating mitophagy via PTP1B pathway

Fig. 2

A Immunofluorescence staining of rat retina using DHE. Red fluorescence represented ROS production (scale bar = 30 μm). B Measurement of the intensity of red fluorescence (n = 3). C Representative images of TUNEL (red) and DAPI (blue) in retinal sections in each group (scale bar = 15 μm). D The bar graph depicts the mean percentages of apoptotic cells (n = 4). E-H Protein expression levels of BCL-2, BAX and PTP1B in retina, as determined by western blot (n = 3). *P < 0.05, **P < 0.01, ***P < 0.001.

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