Fig. 4: sEVs inhibited AGEs-induced oxidative stress and apoptosis through PTP1B pathway. | Cell Death Discovery

Fig. 4: sEVs inhibited AGEs-induced oxidative stress and apoptosis through PTP1B pathway.

From: MiR-125a-5p in MSC-derived small extracellular vesicles alleviates Müller cells injury in diabetic retinopathy by modulating mitophagy via PTP1B pathway

Fig. 4

A, B Protein expression levels of PTP1B in Müller cells, as determined by western blot (n = 3). C Schematic diagram of cell treatment. D Immunofluorescence staining of the uptake of DiD-labeled sEVs (red) in Müller cells (scale bar = 10 μm). E The intracellular levels of ROS were measured (n = 4). F, G Flow cytometry analysis of pericytes for apoptosis and quantification (n = 3). H-J Protein expression levels of BCL-2 and BAX in Müller cells, as determined by western blot (n = 3). *P < 0.05, **P < 0.01, ***P < 0.001.

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