Fig. 2: Apoptosis of spermatogenic cells increases with time in wild-type (WT) mice after cryptorchidism. | Cell Death Discovery

Fig. 2: Apoptosis of spermatogenic cells increases with time in wild-type (WT) mice after cryptorchidism.

From: The involvement of TRPV1 in the apoptosis of spermatogenic cells in the testis of mice with cryptorchidism

Fig. 2

A Schematic diagram of surgery-induced cryptorchidism in mice. Bilateral cryptorchidism was performed in 8-week-old mice. Comparison of the testicular size (B), testicular weight (C), testicular weight/body weight ratio (D) and the number of spermatozoa in cauda epididymis (E) on days 3, 6, 9, 12 and 15 after cryptorchidism (n = 5). F H&E staining of mouse testes and cauda epididymis on days 3, 6, 9, 12 and 15 after cryptorchidism. The arrows represent multinucleated giant cells. G Sections of testes on days 3, 6, 9, 12 and 15 after cryptorchidism were stained with the TUNEL probe (green), and nuclei were stained with DAPI (blue). Histogram showing the quantification of TUNEL positive tubules (H) and TUNEL positive cells per tubule (I) on days 3, 6, 9, 12 and 15 in cryptorchid testes (n = 3). Data were represented as mean ± SD from three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001 by Student’s t test.

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